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What is Ocular Melanoma

a link to the what is ocular melanoma area of the website

Treatment

Doctor with patient

Spread

red cells flowing in a vein

June 2020 - The Hallmarks of Ferroptosis

This is an interesting paper discussing ferroptosis of which ocular melanoma is said to be susceptible. Ferroptosis is a nonapoptotic, iron-dependent form of cell death that can be activated in cancer cells by natural stimuli and synthetic agents. Three essential hallmarks define ferroptosis, namely: the loss of lipid peroxide repair capacity by the phospholipid hydroperoxidase GPX4, the availability of redoxactive iron, and oxidation of polyunsaturated fatty acid (PUFA)-containing phospholipids.

Apr 2020 - Niclosamide inhibits uveal melanoma in tests

We have known about this drug for a while as it is a favourite in the metabolic treatment of cancers. There is a good listing of its potential in various cancer settings  HERE. In 2017 lab testing was carried out to see the relevance of this antihelminthic drug niclosamide which showed that it effectively inhibits the malignant phenotypes of uveal melanoma in vitro and in vivo.

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